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More importantly, treatment with APG-157 led to a reduction in pro-inflammatory cytokines IL-1β, IL-6, and IL-8 in the saliva of these cancer patients ( A Phase II trial (ongoing or recently completed) is testing APG-157 in combination with a checkpoint inhibitor (immunotherapy) in oral cancer, based on preclinical suggestions that curcumin may improve anti-tumor immunity (Xiang et al., 2019)
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